Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Use of human umbilical vein endothelial cells (HUVEC) as a model to study cardiovascular disease: A review

DJ Medina-Leyte, M Domínguez-Pérez, I Mercado… - Applied Sciences, 2020 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

Recent advances in antenatal factors predisposing to bronchopulmonary dysplasia

E Taglauer, SH Abman, RL Keller - Seminars in perinatology, 2018 - Elsevier
Bronchopulmonary dysplasia (BPD) remains a major cause of late morbidities and death
after preterm birth. BPD is characterized by an arrest of vascular and alveolar growth and …

Human peripheral blood-derived endothelial colony-forming cells are highly similar to mature vascular endothelial cells yet demonstrate a transitional transcriptomic …

AG Kutikhin, AE Tupikin, VG Matveeva, DK Shishkova… - Cells, 2020 - mdpi.com
Endothelial colony-forming cells (ECFC) are currently considered as a promising cell
population for the pre-endothelialization or pre-vascularization of tissue-engineered …

Shear stress: An essential driver of endothelial progenitor cells

AG Kutikhin, MY Sinitsky, AE Yuzhalin… - Journal of Molecular and …, 2018 - Elsevier
The blood flow through vessels produces a tangential, or shear, stress sensed by their
innermost layer (ie, endothelium) and representing a major hemodynamic force. In humans …

Prospective surface marker-based isolation and expansion of fetal endothelial colony-forming cells from human term placenta

J Patel, E Seppanen, MSK Chong… - Stem cells …, 2013 - academic.oup.com
The term placenta is a highly vascularized tissue and is usually discarded upon birth. Our
objective was to isolate clinically relevant quantities of fetal endothelial colony-forming cells …

Exercise training effects on circulating endothelial and progenitor cells in heart failure

C Kourek, A Briasoulis, V Zouganeli… - Journal of …, 2022 - mdpi.com
Heart failure (HF) is a major public health issue worldwide with increased prevalence and a
high number of hospitalizations. Patients with chronic HF and either reduced ejection …

Endothelial progenitor cells in cardiovascular diseases

Y Qiu, C Zhang, G Zhang, J Tao - Aging medicine, 2018 - Wiley Online Library
Cardiovascular diseases (CVDs) are the leading cause of death in both developed and
developing countries. Endothelial progenitor cells (EPCs) are derived from hematopoietic …

Mesenchymal stem/stromal cells enhance engraftment, vasculogenic and pro-angiogenic activities of endothelial colony forming cells in immunocompetent hosts

A Shafiee, J Patel, JS Lee, DW Hutmacher, NM Fisk… - Scientific reports, 2017 - nature.com
The clinical use of endothelial colony forming cells (ECFC) is hampered by their restricted
engraftment. We aimed to assess engraftment, vasculogenic and pro-angiogenic activities of …

Priming of endothelial colony‐forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition …

A Shafiee, J Patel, H Yi Wong, P Donovan… - The FASEB …, 2017 - Wiley Online Library
The prospect of using endothelial progenitors is currently hampered by their low engraftment
upon transplantation. We report that mesenchymal stem/stromal cells (MSCs), independent …