Somatic cell nuclear transfer reprogramming: mechanisms and applications

S Matoba, Y Zhang - Cell stem cell, 2018 - cell.com
Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …

[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging

JH Yang, M Hayano, PT Griffin, JA Amorim… - Cell, 2023 - cell.com
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Molecular obstacles to clinical translation of iPSCs

N Tapia, HR Schöler - Cell stem cell, 2016 - cell.com
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using
defined factors provides new tools for biomedical research. However, some iPSC clones …

[HTML][HTML] RETRACTED ARTICLE: Stimulus-triggered fate conversion of somatic cells into pluripotency

H Obokata, T Wakayama, Y Sasai, K Kojima… - Nature, 2014 - nature.com
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered
acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the …

Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing

K Fischer, S Kraner-Scheiber, B Petersen… - Scientific reports, 2016 - nature.com
Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for
transplantation. Means have been identified to overcome hyperacute rejection and acute …

Human somatic cell nuclear transfer using adult cells

YG Chung, JH Eum, JE Lee, SH Shim, V Sepilian… - Cell stem cell, 2014 - cell.com
Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer
(SCNT) has the potential for applications in a range of therapeutic contexts. However …

β-Cell replacement in mice using human type 1 diabetes nuclear transfer embryonic stem cells

L Sui, N Danzl, SR Campbell, R Viola, D Williams… - Diabetes, 2018 - Am Diabetes Assoc
β-Cells derived from stem cells hold great promise for cell replacement therapy for diabetes.
Here we examine the ability of nuclear transfer embryonic stem cells (NT-ESs) derived from …

Healthy cloned offspring derived from freeze-dried somatic cells

S Wakayama, D Ito, E Hayashi, T Ishiuchi… - Nature …, 2022 - nature.com
Maintaining biodiversity is an essential task, but storing germ cells as genetic resources
using liquid nitrogen is difficult, expensive, and easily disrupted during disasters. Our aim is …

Report of the key opinion leaders meeting on stem cell-derived beta cells

J Odorico, J Markmann, D Melton, J Greenstein… - …, 2018 - journals.lww.com
Beta cell replacement has the potential to restore euglycemia in patients with insulin-
dependent diabetes. Although great progress has been made in establishing allogeneic …

Anti-aging strategies based on cellular reprogramming

A Ocampo, P Reddy, JCI Belmonte - Trends in molecular medicine, 2016 - cell.com
Aging can be defined as the progressive decline in the ability of a cell or organism to resist
stress and disease. Recent advances in cellular reprogramming technologies have enabled …