[HTML][HTML] Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice

EG Ferrarini, RS Paes, GM Baldasso… - Biomedicine & …, 2022 - Elsevier
Fibromyalgia (FM) is an idiopathic disorder characterized by generalized pain and
associated symptoms such as depression and anxiety. Cannabis sativa shows different …

The involvement of K+ channels in depression and pharmacological effects of antidepressants on these channels

XT Li - Translational Psychiatry, 2024 - nature.com
Depression is a common and complex psychiatric illness with multiple clinical symptoms,
even leading to the disability and suicide. Owing to the partial understanding of the …

Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT2A/C Receptors

CS Garcia, EM Besckow… - ACS Chemical …, 2022 - ACS Publications
The monoaminergic dysfunction plays a central role in major depressive disorder (MDD), a
mental disturbance associated with constant feeling of sadness and lack of interest. The …

Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl) benzofuran in mice

JI Gall, AG Alves, LRC Júnior, TST Rech… - Progress in Neuro …, 2020 - Elsevier
Monoaminergic and oxidative dysfunctions have been reported to play a role in depression.
The present study investigated the antioxidant potential as well as the antidepressant-like …

Antidepressant-like effect of a selenopropargylic benzamide in mice: involvement of the serotonergic system

EM Besckow, NT Nonemacher, CS Garcia… - …, 2020 - Springer
Rationale Major depressive disorder is a psychiatric disorder that requires considerable
attention, since it dramatically impairs the quality of life of the sufferers. The available …

Exercise reduces pain and deleterious histological effects in fibromyalgia-like model

EG Ferrarini, ECD Gonçalves, JF Menegasso… - Neuroscience, 2021 - Elsevier
Fibromyalgia (FM) is characterized by chronic pain and associated comorbidities such as
fatigue, anxiety, depression, and sleep disorders. There is a large amount of evidence …

N-(3-((3-(trifluoromethyl) phenyl) selanyl) prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system

CS Pires, MJ da Rocha, MH Presa, NP Zuge… - …, 2024 - Springer
Objective To evaluate the antidepressant-like effect of N-(3-((3-(trifluoromethyl) phenyl)
selenyl) prop-2-yn-1-yl) benzamide (CF 3 SePB) in mice and the involvement of the …

Psychotropic effects of a new pyrazolo [C] pyridine derivate GIZh-72 are related to functional activity of atp-sensitive potassium channels

KA Kasabov, NV Kudryashov, AV Volkova… - Bulletin of Experimental …, 2020 - Springer
We studied the influence of intraperitoneal injection of ATP-sensitive potassium channels
inhibitor glibenclamide in doses of 0.01, 0.1, 1, and 10 mg/kg on the effects of a new …

Inhibition of potassium sensitive adenosine triphosphate channels potentiates anti-depressant activity of creatine in mice

EO Okwuofu, LO Iniaghe, B Mahmud… - … African Journal of …, 2022 - wapcpjournal.org.ng
Background: Depression is a mood disorder with poorly understood aetiology and treatment
outcomes. Treatment with creatine, a nutraceutical associated with potassium sensitive …

Effect of dextromethorphan in the mouse forced swim and tail suspension tests: Evidence for involvement of the alpha receptors

S Shakiba, N Fakhraei, MI Khan, F Rastmanesh… - Learning and …, 2021 - Elsevier
Depression is a state of low mood that can seriously affect the quality of life of society.
Therefore, finding new antidepressant agents with high efficacy is needed …