Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is
overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and …

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps.
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …

BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …

POLθ promotes repair of DNA double-strand breaks (DSBs) resulting from collapsed forks in
homologous recombination (HR) defective tumors. Inactivation of POLθ results in synthetic …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and
processing of unligated Okazaki fragments and other DNA replication intermediates …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …