Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Heparanase is an endoglucuronidase that cleaves heparan sulfate chains of proteoglycans.
In many malignancies, high heparanase expression and activity correlate with an …

Heparanase has regulatory roles in various processes, including cell communication, gene
transcription and autophagy. In addition, it is the only known mammalian endoglycosidase …

Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It
is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement …

Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar
enzymatic activity towards HS chains but which simultaneously performs other non …

NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the
core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human …

Syndecan‐1, a cell surface heparan sulfate proteoglycan, is critically involved in the
differentiation and prognosis of various tumors. In this review, we highlight the synthesis …