Human dendritic cell subsets: an update
Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …
haematopoiesis that form an essential interface between the innate sensing of pathogens …
Dendritic cell-based immunotherapy
RL Sabado, S Balan, N Bhardwaj - Cell research, 2017 - nature.com
Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in …
harnessing the potential of a patient's own immune system to eliminate tumor cells in …
Vaccine adjuvants to engage the cross-presentation pathway
Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …
[HTML][HTML] Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
AR Sánchez-Paulete, A Teijeira, FJ Cueto, S Garasa… - Annals of …, 2017 - Elsevier
Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …
The function of Fcγ receptors in dendritic cells and macrophages
M Guilliams, P Bruhns, Y Saeys, H Hammad… - Nature Reviews …, 2014 - nature.com
Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens
and to receive feedback control from adaptive immune cells. Although it was long believed …
and to receive feedback control from adaptive immune cells. Although it was long believed …
Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …
Adjuvants enhancing cross-presentation by dendritic cells: the key to more effective vaccines?
NI Ho, LGM Huis in't Veld, TK Raaijmakers… - Frontiers in …, 2018 - frontiersin.org
Over the last decades, vaccine development has advanced significantly in pursuing higher
safety with less side effects. However, this is often accompanied by a reduction in vaccine …
safety with less side effects. However, this is often accompanied by a reduction in vaccine …
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is
exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor …
exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor …
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses
G Nizzoli, J Krietsch, A Weick… - Blood, The Journal …, 2013 - ashpublications.org
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice,
CD8α+ DC are specialized to cross-prime CD8+ T cells and produce interleukin-12 (IL-12) …
CD8α+ DC are specialized to cross-prime CD8+ T cells and produce interleukin-12 (IL-12) …
Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells
Purpose: Thus far, dendritic cell (DC)-based immunotherapy of cancer was primarily based
on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation …
on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation …