Prospects of RNA interference therapy for cancer
RNA interference (RNAi) is a powerful gene-silencing process that holds great promise in
the field of cancer therapy. The discovery of RNAi has generated enthusiasm within the …
the field of cancer therapy. The discovery of RNAi has generated enthusiasm within the …
Amplified therapeutic targets in high-grade serous ovarian carcinoma–a review of the literature with quantitative appraisal
T Talbot, H Lu, EO Aboagye - Cancer Gene Therapy, 2023 - nature.com
High-grade serous ovarian carcinoma is a unique cancer characterised by universal TP53
mutations and widespread copy number alterations. These copy number alterations include …
mutations and widespread copy number alterations. These copy number alterations include …
Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer
Abstract Purpose: The phosphatidylinositol 3′-kinase (PI3K) family plays a key regulatory
role in various cancer-associated signal transduction pathways. Here, we investigated the …
role in various cancer-associated signal transduction pathways. Here, we investigated the …
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCι as a biomarker and potential oncogene in ovarian carcinoma
The protein kinase C (PKC) family plays a key regulatory role in a wide range of cellular
functions as well as in various cancer-associated signal transduction pathways. Here, we …
functions as well as in various cancer-associated signal transduction pathways. Here, we …
Hypoxia inducible factor 1-α regulates of platelet derived growth factor-B in human glioblastoma cells
D Yoshida, K Kim, M Noha, A Teramoto - Journal of neuro-oncology, 2006 - Springer
Hypoxia inducible factors (HIF) are transcription factors regulating expression of several
genes related to oxygen homeostasis in response to hypoxic stress. Although HIF1-α and …
genes related to oxygen homeostasis in response to hypoxic stress. Although HIF1-α and …
Modulating the expression of disease genes with RNA-based therapy
M Wood, H Yin, G McClorey - PLoS genetics, 2007 - journals.plos.org
Conventional gene therapy has focused largely on gene replacement in target cells.
However, progress from basic research to the clinic has been slow for reasons relating …
However, progress from basic research to the clinic has been slow for reasons relating …
Mutant PIK3CA-Bearing Colon Cancer Cells Display Increased Metastasis in an Orthotopic Model
XN Guo, A Rajput, R Rose, J Hauser, A Beko… - Cancer research, 2007 - AACR
Mutations in the PIK3CA gene are common in human cancers, including colon cancer. We
compared two pairs of colon cancer cells (HCT116 and DLD1) bearing only the wild-type …
compared two pairs of colon cancer cells (HCT116 and DLD1) bearing only the wild-type …
Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment
N Yang, J Huang, J Greshock, S Liang, A Barchetti… - PLoS …, 2008 - journals.plos.org
PIK3CA upregulation, amplification and mutation have been widely reported in ovarian
cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic …
cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic …
Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
J Jeong, KS Kim, JS Moon, J Song, S Choi, K Kim… - Apoptosis, 2013 - Springer
Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling
cascades playing important roles in the chemoresistance of human cancer cells, including …
cascades playing important roles in the chemoresistance of human cancer cells, including …
Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities
Background Breast cancer is the second most frequent type of cancer affecting women. We
are increasingly aware that changes in mRNA splicing are associated with various …
are increasingly aware that changes in mRNA splicing are associated with various …