How can machine learning and multiscale modeling benefit ocular drug development?
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …
drug delivery space, distinctive barriers, and complicated biomechanical processes …
[HTML][HTML] Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration
Several chronic eye diseases affect the posterior segment of the eye. Among them age-
related macular degeneration can cause vision loss if left untreated and is one of the leading …
related macular degeneration can cause vision loss if left untreated and is one of the leading …
Polymeric Micelles Loaded In Situ Gel with Prednisolone Acetate for Ocular Inflammation: Development and Evaluation
Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular
inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration …
inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration …
Advancing treatment of retinal disease through in silico trials
RJ Hernandez, PA Roberts… - Progress in Biomedical …, 2023 - iopscience.iop.org
Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …
Image-based insilico investigation of hemodynamics and biomechanics in healthy and diabetic human retinas
Retinal hemodynamics and biomechanics play a significant role in understanding the
pathophysiology of several ocular diseases. However, these parameters are significantly …
pathophysiology of several ocular diseases. However, these parameters are significantly …
A review on polymeric nanostructured micelles for the ocular inflammation-main emphasis on uveitis
Background: Various types of nano-formulations are being developed and tested for the
delivery of the ocular drug. They also have anatomical and physiological limitations, such as …
delivery of the ocular drug. They also have anatomical and physiological limitations, such as …
[HTML][HTML] Numerical simulation and analysis of the temporal concentration of timolol after topical administration in the human eye
The temporal distribution of drugs in the eye tissues after the topical dosing is required to
study the efficacy of the drugs. Glaucoma is one of the primary causes of vision impairment …
study the efficacy of the drugs. Glaucoma is one of the primary causes of vision impairment …
Anatomical and Micro-CT measurement analysis of ocular volume and intraocular volume in adult Bama Miniature pigs, New Zealand rabbits, and Sprague-Dawley …
Y Wu, Y Feng, J Yang, Y Ran, Z Shu, X Cen, W Li - Plos one, 2024 - journals.plos.org
Aim Utilizing a combination of micro-computed tomography (micro-CT) and anatomical
techniques for the volumetric assessment of the eyeball and its constituents in Bama …
techniques for the volumetric assessment of the eyeball and its constituents in Bama …
Mathematical models of drug delivery via a contact lens during wear
DM Anderson, RA Luke - La Matematica, 2024 - Springer
In this work we develop and investigate mathematical and computational models that
describe drug delivery from a contact lens during wear. Our models are designed to predict …
describe drug delivery from a contact lens during wear. Our models are designed to predict …
Delineating the effects of morphological changes on retinal hemodynamics in diabetic human retinas: An invitro investigation
Diabetes-related vascular abnormalities are commonly encountered in the retinal
vasculature, the most common being the increased tortuosity and reduced lumen diameter …
vasculature, the most common being the increased tortuosity and reduced lumen diameter …