The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor
CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …
KATP Channels in the Cardiovascular System
MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …
electrophysiological methods has allowed for a detailed characterization of KATP channels …
KATP channels as molecular sensors of cellular metabolism
CG Nichols - Nature, 2006 - nature.com
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …
activity provides a unique link between cellular energetics and electrical excitability. Over …
ATP-Sensitive potassium channels and their physiological and pathophysiological roles.
ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection
TP Flagg, D Enkvetchakul, JC Koster… - Physiological …, 2010 - journals.physiology.org
ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …
Sulphonylurea action revisited: the post-cloning era
FM Gribble, F Reimann - Diabetologia, 2003 - Springer
Hypoglycaemic agents such as sulphonylureas and the newer group of" glinides" stimulate
insulin secretion by closing ATP-sensitive potassium (K ATP) channels in pancreatic beta …
insulin secretion by closing ATP-sensitive potassium (K ATP) channels in pancreatic beta …
A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …
Limitations in intense exercise performance of athletes–effect of speed endurance training on ion handling and fatigue development
M Hostrup, J Bangsbo - The Journal of physiology, 2017 - Wiley Online Library
Mechanisms underlying fatigue development and limitations for performance during intense
exercise have been intensively studied during the past couple of decades. Fatigue …
exercise have been intensively studied during the past couple of decades. Fatigue …
KATP channels and preconditioning: a re-examination of the role of mitochondrial KATP channels and an overview of alternative mechanisms
PJ Hanley, J Daut - Journal of molecular and cellular cardiology, 2005 - Elsevier
Preconditioning by one or several brief periods of ischemia activates an endogenous
cardioprotective program that increases the resistance of cardiomyocytes to injury by …
cardioprotective program that increases the resistance of cardiomyocytes to injury by …
SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator
J Aittoniemi, C Fotinou, TJ Craig… - … of the Royal …, 2009 - royalsocietypublishing.org
SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other
ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive …
ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive …