Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …

Over the last years, repurposed agents have provided growing evidence of fast
implementation in oncology treatment such as certain antimalarial, anthelmintic, antibiotics …

Prostate cancer (PCa) causes deaths worldwide, ranking second after lung cancer. Bone
metastasis (BM) frequently results from advanced PCa, affecting approximately 90% of …

Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an
overall good rate of survival, however there is a percentage of patients that do not respond …

Metformin is a synthetic biguanide that improves insulin sensitivity and reduces hepatic
gluconeogenesis. Aside being the first-line therapy for Type 2 Diabetes (T2D), many …

Background It has been reported that metformin use may reduce the risk of thyroid cancer,
but existing studies have generated inconsistent results. The purpose of this study was to …

Simple Summary Mitochondria are organelles involved in different biological processes,
including tumorigenesis. Accumulating evidence strongly supports that, despite the …

Liver cancer has a high incidence and mortality rate worldwide, with hepatocellular
carcinoma (HCC) being the most common histological type. With the decrease in the …

Background Hepatic lipid accumulation is one of the main pathological features of alcoholic
liver disease (ALD). Metformin serves as an AMPK activator and has been shown to have …

Metformin has been used for the treatment of type II diabetes mellitus for decades due to its
safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying …