Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

Two alternative strategies are commonly used to study protein–protein interactions (PPIs)
and to engineer protein-based inhibitors. In one approach, binders are selected …

Modular protein interaction domains form the building blocks of eukaryotic signaling
pathways. Many of them, known as peptide recognition domains, mediate protein …

Selective dimerization of the basic-region leucine-zipper (bZIP) transcription factors presents
a vivid example of how a high degree of interaction specificity can be achieved within a …

Background PDZ domains are structural protein domains that recognize simple linear amino
acid motifs, often at protein C-termini, and mediate protein-protein interactions (PPIs) in …

Protein-protein interactions play crucial and subtle roles in many biological processes and
modifications of their fine mechanisms generally result in severe diseases. Peptide …

Peptide-binding domains play a critical role in regulation of cellular processes by mediating
protein interactions involved in signalling. In recent years, the development of large-scale …

Protein–protein interactions (PPIs), involved in many biological processes such as cellular
signaling, are ultimately encoded in the genome. Solving the problem of predicting protein …

Domain–peptide recognition and interaction are fundamentally important for eukaryotic
signaling and regulatory networks. It is thus essential to quantitatively infer the binding …

Protein–protein interactions that involve recognition of short peptides are critical in cellular
processes. Protein–peptide interaction surface areas are relatively small and shallow, and …