The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs
in skeletal muscle in response to both exercise training and prolonged periods of disuse …

The diaphragm is the main inspiratory muscle, and its dysfunction can lead to significant
adverse clinical consequences. The aim of this review is to provide clinicians with an …

Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-
generating capacity. This disuse-induced muscle atrophy results from both increased …

Skeletal muscles comprise the largest organ system in the body and play an essential role in
body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important …

It is well established that long durations of bed rest, limb immobilization, or reduced activity
in respiratory muscles during mechanical ventilation results in skeletal muscle atrophy in …

Prolonged periods of muscular inactivity (eg, limb immobilization) result in skeletal muscle
atrophy. Although it is established that reactive oxygen species (ROS) play a role in inactivity …

Sepsis is a major cause of morbidity and mortality in critically ill patients, and despite
advances in management, mortality remains high. In survivors, sepsis increases the risk for …

Background: Mechanical ventilation is a life-saving intervention used to provide adequate
pulmonary ventilation in patients suffering from respiratory failure. However, prolonged …

Rationale: Controlled mechanical ventilation (CMV) results in atrophy of the human
diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle …