Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

Background: Osteoarthritis (OA) is a common degenerative joint disease. The pathogenesis
of OA is closely related to inflammatory responses and apoptosis of chondrocytes …

Aging is consistently reported as the most important independent risk factor for
neurodegenerative diseases. As life expectancy has significantly increased during the last …

Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Knee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to
chronic pain, edema, and limited mobility of knee joint. Traditional Chinese Medicine (TCM) …

Osteochondral defects are characterized by injuries to both cartilage and subchondral bone,
which is a result of trauma, inflammation, or inappropriate loading. Due to the unique …

Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines,
including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and …