B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities
CM Laumont, AC Banville, M Gilardi, DP Hollern… - Nature Reviews …, 2022 - nature.com
Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …
Dual effect of immune cells within tumour microenvironment: pro-and anti-tumour effects and their triggers
AC Peña-Romero, E Orenes-Piñero - Cancers, 2022 - mdpi.com
Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …
B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity
CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
Immune microenvironment in osteosarcoma: components, therapeutic strategies and clinical applications
T Zhu, J Han, L Yang, Z Cai, W Sun, Y Hua… - Frontiers in …, 2022 - frontiersin.org
Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …
and the 5-year event-free survival rate has not improved significantly in the past three …
B cells and tertiary lymphoid structures: friends or foes in cancer immunotherapy?
Tumor cells pose a challenge to the adaptive immune system, and its key cell types, T and B
cells, have frequently been associated with an improved prognosis. The success of immune …
cells, have frequently been associated with an improved prognosis. The success of immune …
Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance …
Background Novel immunotherapy combination therapies have improved outcomes for
patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of …
patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of …
Immune checkpoint blockade in pancreatic cancer: trudging through the immune desert
Pancreatic cancer (PC) has exceptionally high mortality due to ineffective treatment
strategies. Immunotherapy, which mobilizes the immune system to fight against cancer, has …
strategies. Immunotherapy, which mobilizes the immune system to fight against cancer, has …
Biomarkers for immune checkpoint inhibition in sarcomas–are we close to clinical implementation?
Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains
poorly understood. Recent developments in cancer immunotherapy have demonstrated a …
poorly understood. Recent developments in cancer immunotherapy have demonstrated a …
Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas
GS Kinker, GAF Vitiello, AB Diniz, MP Cabral-Piccin… - Gut, 2023 - gut.bmj.com
Objective To better understand the immune microenvironment of pancreatic ductal
adenocarcinomas (PDACs), here we explored the relevance of T and B cell …
adenocarcinomas (PDACs), here we explored the relevance of T and B cell …