High-altitude erythrocytosis: mechanisms of adaptive and maladaptive responses
FC Villafuerte, TS Simonson, D Bermudez… - …, 2022 - journals.physiology.org
Erythrocytosis, or increased production of red blood cells, is one of the most well-
documented physiological traits that varies within and among in high-altitude populations …
documented physiological traits that varies within and among in high-altitude populations …
Cardiovascular physiology and pathophysiology at high altitude
JP Richalet, E Hermand, FJ Lhuissier - Nature Reviews Cardiology, 2024 - nature.com
Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …
Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders
ES Lawrence, W Gu, RJ Bohlender… - Science …, 2024 - science.org
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
Gut microbiota imbalance mediates intestinal barrier damage in high‐altitude exposed mice
Y Wang, Y Shi, W Li, S Wang, J Zheng, G Xu… - The FEBS …, 2022 - Wiley Online Library
The environmental conditions in high‐altitude areas can induce gastrointestinal disorders
and changes in gut microbiota. The gut microbiota is closely related to a variety of …
and changes in gut microbiota. The gut microbiota is closely related to a variety of …
Cardiac remodelling in the highest city in the world: effects of altitude and chronic mountain sickness
S Doutreleau, M Ulliel-Roche, I Hancco… - European Journal of …, 2022 - academic.oup.com
Aims A unique Andean population lives in the highest city of the world (La Rinconada, 5100
m, Peru) and frequently develops a maladaptive syndrome, termed chronic mountain …
m, Peru) and frequently develops a maladaptive syndrome, termed chronic mountain …
Nocturnal hypoxemia, blood pressure, vascular status and chronic mountain sickness in the highest city in the world
Introduction Chronic mountain sickness (CMS) is a condition characterized by excessive
erythrocytosis in response to chronic hypobaric hypoxia. CMS frequently triggers …
erythrocytosis in response to chronic hypobaric hypoxia. CMS frequently triggers …
[HTML][HTML] Time domains of hypoxia responses and-omics insights
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life.
Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and …
Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and …
[HTML][HTML] A study of survival strategies for improving acclimatization of lowlanders at high-altitude
P Sharma, S Mohanty, Y Ahmad - Heliyon, 2023 - cell.com
Human Acclimatization and therapeutic approaches are the core components for
conquering the physiological variations at high altitude (≥ 2500 m) exposure. The declined …
conquering the physiological variations at high altitude (≥ 2500 m) exposure. The declined …
Heterogeneity in hematological parameters of high and low altitude Tibetan populations
Introduction High altitude hypoxia is believed to be experienced at elevations of more than
2500 meters above sea level. Several studies have shed light on the biochemical aspects of …
2500 meters above sea level. Several studies have shed light on the biochemical aspects of …
[PDF][PDF] Excessive erythrocytosis and chronic mountain sickness in the highest city in the world: A longitudinal study
B Champigneulle, I Hancco, E Hamard, S Doutreleau… - Chest, 2022 - Elsevier
Methods Between 2005 and 2019, we conducted a longitudinal follow-up of 90 male
dwellers from La Rinconada (5,100-5,300 m), a gold mining town located in southeastern …
dwellers from La Rinconada (5,100-5,300 m), a gold mining town located in southeastern …