Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …

Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death. Tumor
lysis syndrome can occur as a consequence of tumor targeted therapy or spontaneously …

Importance Allopurinol, a first-line drug used for treating gout, is increasingly prescribed
worldwide to patients with asymptomatic hyperuricemia and comorbid renal or …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive
cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of …

Background Adenine phosphoribosyltransferase (APRT) deficiency is a purine metabolism
disorder causing kidney stones and chronic kidney disease (CKD). The course of …

Background: Accruing evidence suggests that Xanthine Oxidase inhibitors (XOis) may bring
direct renal benefits, besides those related to their hypo-uricemic effect. We hence aimed at …

Hyperuricemia is a frequent complication of chronic kidney disease (CKD). Febuxostat is a
novel xanthine oxidase inhibitor that is metabolized by many metabolic pathways in the …

OBJECTIVE: In patients with gout, serum uric acid (sUA) concentrations should be lowered
at least below the target of 6 mg/dL (even below 5 mg/dL in patients with severe gout). To …

OBJECTIVE: To evaluate the effect of Dahuang Mudan Tang (大黄牡丹汤, DHMD) and
allopurinol on the treatment of chronic kidney disease staged G1-G3b patients with …

Allopurinol Against Progression of Chronic Kidney Disease Page 1 KIDNEY DISEASES 286
Original P aper Iranian Journal of Kidney Diseases | Volume 11 | Number 4 | July 2017 …