Oxidative stress in autism spectrum disorder—current progress of mechanisms and biomarkers

X Liu, J Lin, H Zhang, NU Khan, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been
diagnosed in an increasing number of children around the world. Existing data suggest that …

Glutathione synthesis

SC Lu - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Metabolomics reveal nanoplastic-induced mitochondrial damage in human liver and lung cells

S Lin, H Zhang, C Wang, XL Su, Y Song… - … science & technology, 2022 - ACS Publications
Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs)
toxicity in humans is far from being understood. Studies have indicated that NPs can affect …

Ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system

ML Contreras-Zentella, D Villalobos-García… - Antioxidants, 2022 - mdpi.com
The liver metabolizes ethanol through three enzymatic pathways: alcohol dehydrogenase
(ADH), cytochrome p450 (also called MEOS), and catalase. Alcohol dehydrogenase class I …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

DA Rossignol, RE Frye - Molecular psychiatry, 2012 - nature.com
A comprehensive literature search was performed to collate evidence of mitochondrial
dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features …

Regulation of glutathione synthesis

SC Lu - Molecular aspects of medicine, 2009 - Elsevier
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

DA Rossignol, RE Frye - Frontiers in physiology, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders that are defined solely on the basis of behavioral observations. Therefore, ASD …

Glutathione in cancer biology and therapy

JM Estrela, A Ortega, E Obrador - Critical reviews in clinical …, 2006 - Taylor & Francis
The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic
mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant …

Crosstalk between neuroinflammation and oxidative stress in epilepsy

T Fabisiak, M Patel - Frontiers in cell and developmental biology, 2022 - frontiersin.org
The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …