The lung microbiome, immunity, and the pathogenesis of chronic lung disease
DN O'Dwyer, RP Dickson, BB Moore - The journal of immunology, 2016 - journals.aai.org
The development of culture-independent techniques for microbiological analysis has
uncovered the previously unappreciated complexity of the bacterial microbiome at various …
uncovered the previously unappreciated complexity of the bacterial microbiome at various …
Biomarkers in the diagnosis and prognosis of sarcoidosis: current use and future prospects
R Kraaijvanger, M Janssen Bonás… - Frontiers in …, 2020 - frontiersin.org
Sarcoidosis is a heterogeneous disease in terms of presentation, duration, and severity. Due
to this heterogeneity, it is difficult to align treatment decisions. Biomarkers have proved to be …
to this heterogeneity, it is difficult to align treatment decisions. Biomarkers have proved to be …
The immunoregulatory landscape of human tuberculosis granulomas
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …
infected tissues, the architecture and composition of which are thought to affect disease …
[HTML][HTML] Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
T Krausgruber, A Redl, D Barreca, K Doberer… - Immunity, 2023 - cell.com
Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …
appear unstructured, yet they have some resemblance to lymphoid organs. To better …
JCS 2016 Guideline on diagnosis and treatment of cardiac sarcoidosis―Digest version―
F Terasaki, A Azuma, T Anzai, N Ishizaka… - Circulation …, 2019 - jstage.jst.go.jp
Sarcoidosis is a systemic granulomatous disease of unknown cause. Sarcoidosis involving
the heart, ie, cardiac sarcoidosis, affects the prognosis of patients significantly as it may lead …
the heart, ie, cardiac sarcoidosis, affects the prognosis of patients significantly as it may lead …
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis
Sarcoidosis is an idiopathic inflammatory disorder that is commonly treated with
glucocorticoids. An imprecise understanding of the immunologic changes underlying …
glucocorticoids. An imprecise understanding of the immunologic changes underlying …
Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working …
ALP Caforio, Y Adler, C Agostini, Y Allanore… - European heart …, 2017 - academic.oup.com
Systemic immune-mediated diseases (SIDs) include autoimmune and autoinflammatory
diseases (AD) affecting at least two-organ systems. 1 Autoinflammatory diseases refer to a …
diseases (AD) affecting at least two-organ systems. 1 Autoinflammatory diseases refer to a …
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis
Z Zhong, G Su, A Kijlstra, P Yang - Progress in retinal and eye research, 2021 - Elsevier
Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
CT Weaver, CO Elson, LA Fouser… - Annual Review of …, 2013 - annualreviews.org
The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
IFN-γ–producing T-helper 17.1 cells are increased in sarcoidosis and are more prevalent than T-helper type 1 cells
J Ramstein, CE Broos, LJ Simpson… - American journal of …, 2016 - atsjournals.org
Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …