Exosomes are small nanoparticles secreted by almost all cells and have a well-known role
in intercellular communication. They are found in different body fluids and can also be …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

Heavy metals are discharged into aquatic environment and causes serious problems to the
environment, human's health, and other organisms. The industrial effluents contain high …

The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects
underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) …

Bone marrow-derived mesenchymal stem cells (MSC) have unique immunomodulatory and
reparative properties beneficial for allotransplantation cellular therapy. The clinical …

Drug-induced nephrotoxicity still hampers drug development, because current translation
from in vitro or animal studies to human lacks high predictivity. Often, renal adverse effects …

BACKGROUND: After myocardial infarction (MI) a local inflammatory reaction clears the
damaged myocardium from dead cells and matrix debris at the onset of scar formation. The …

During chronic kidney disease (CKD), drug metabolism is affected leading to changes in
drug disposition. Furthermore, there is a progressive accumulation of uremic retention …

Sepsis remains an important cause of death worldwide, and vigorous immune responses
during sepsis could be beneficial for bacterial clearance but at the price of collateral damage …

Background and Purpose Recently, two phase‐II trials demonstrated improved renal
function in critically ill patients with sepsis‐associated acute kidney injury treated with the …