Abstract The PI3K/AKT/mTOR pathway controls key cellular processes, including
proliferation and tumor progression, and abnormally high activation of this pathway is a …

In recent years, targeted protein degradation (TPD) of plasma membrane proteins by
hijacking the ubiquitin proteasome system (UPS) or the lysosomal pathway has emerged as …

The role of long noncoding RNA (lncRNA) in tumors, particularly in gastrointestinal tumors,
has gained significant attention. Accumulating evidence underscores the interaction …

Metastatic colorectal cancer (CRC) is a common cause of cancer-related mortality, of which
peritoneal metastases (PMs) have the worse outcome. Metastasis-specific markers may help …

Chromatin loops (or chromatin interactions) are important elements of chromatin structures.
Disruption of chromatin loops is associated with many diseases, such as cancer and …

Colorectal cancer (CRC) is a significant health concern and is the third most commonly
diagnosed and second deadliest cancer worldwide. CRC has been steadily increasing in …

Background It has been demonstrated that elevated telomerase reverse transcriptase
(TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition …

Recent findings have suggested that solute carrier (SLC) transporters play an important role
in tumor development and progression, and alterations in the expression of individual SLC …

Current treatments for KRAS-mutant colorectal cancers (CRCs) are often limited by cellular
plasticity and rewiring responses. Here we describe a promising therapeutic strategy that …

Background: Transmembrane E3 ubiquitin ligase (RNF43) mutations are present in
approximately 6–18% of colorectal cancers (CRC) and could enhance Wnt/β-catenin …