High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

Systems biology aims to understand the nonlinear interactions of multiple biomolecular
components that characterize a living organism. One important aspect of systems biology …

Background Many difficult problems in evolutionary genomics are related to mutations that
have weak effects on fitness, as the consequences of mutations with large effects are often …

Introduction: Although multiple efforts have been initiated to shed light into the molecular
mechanisms underlying cardiovascular disease, it still remains one of the major causes of …

In this paper we present a review of progress in addressing the challenge to understand and
describe the vast complexity and multi-level organisation associated with biological systems …

Background Physiological left ventricular hypertrophy (LVH) involves complex cardiac
remodeling that occurs as an adaptive response to chronic exercise. A stark clinical contrast …

Abstract Systems biology based on integrative computational analysis and high technology
is in a position to construct networks, to study the interactions between molecular …

The recent advances in the biological research have produced new biological disciplines
with clinical applications in medicine and cardiology. The integration of multilevel biological …

The necessary overall coordination of cardiac cellular functions is little known at the mRNA
level. Focusing on energy production and cardiac contraction, we analyzed microarray data …

Background: The vessel stenosis and re-stenosis processes are mainly related to cellular
and molecular events. The vascular smooth muscle cell (VSMC) activation is the basic …