Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …

The ubiquitin-related SUMO system controls many cellular signaling networks. In
mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Recent transcriptome analyses show that substantial proportions of eukaryotic genomes can
be copied into RNAs, many of which do not encode protein sequences. However, cells have …

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

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Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin
structures that can respond to changes in the transcriptional requirements of the cell …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …