Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …

Potential clinical utility of liquid biopsies in ovarian cancer

JW Zhu, P Charkhchi, MR Akbari - Molecular cancer, 2022 - Springer
Background Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One
of the main challenges in the management of OC is the late clinical presentation of disease …

Integrated extracellular microRNA profiling for ovarian cancer screening

A Yokoi, J Matsuzaki, Y Yamamoto, Y Yoneoka… - Nature …, 2018 - nature.com
A major obstacle to improving prognoses in ovarian cancer is the lack of effective screening
methods for early detection. Circulating microRNAs (miRNAs) have been recognized as …

Circulating miRNA analysis for cancer diagnostics and therapy

L Valihrach, P Androvic, M Kubista - Molecular Aspects of Medicine, 2020 - Elsevier
Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

MiRNA-210: a current overview

A Bavelloni, G Ramazzotti, A Poli, M Piazzi… - Anticancer …, 2017 - ar.iiarjournals.org
microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …

Reversible zwitterionic coordination enables rapid, high-yield, and high-purity isolation of extracellular vesicles from biofluids

Q Li, Z Zhang, F Wang, X Wang, S Zhan, X Yang… - Science …, 2023 - science.org
Extracellular vesicles (EVs) hold great clinical value as promising diagnostic biomarkers and
therapeutic agents. This field, however, is hindered by technical challenges in the isolation …

Role of microRNAs in obesity and obesity-related diseases

G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Comparative proteomic analysis of exosomes and microvesicles in human saliva for lung cancer

Y Sun, C Huo, Z Qiao, Z Shang… - Journal of proteome …, 2018 - ACS Publications
Extracellular vesicles (EVs) are cell-derived microparticles present in most body fluids,
mainly including microvesicles and exosomes. EV-harbored proteins have emerged as …

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy

K Asakura, T Kadota, J Matsuzaki, Y Yoshida… - Communications …, 2020 - nature.com
Lung cancer, the leading cause of cancer death worldwide, is most frequently detected
through imaging tests. In this study, we investigated serum microRNAs (miRNAs) as a …

Role of biomarker tests for diagnosis of neuroendocrine tumours

J Hofland, WT Zandee, WW de Herder - Nature Reviews Endocrinology, 2018 - nature.com
Neuroendocrine tumours (NETs) are neoplasms that arise from neuroendocrine cells.
Neuroendocrine cells and their tumours can secrete a wide range of amines and …