[HTML][HTML] The BRAIN initiative cell census consortium: lessons learned toward generating a comprehensive brain cell atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of
connectivity is critical for understanding the properties of neural circuits and how they …
connectivity is critical for understanding the properties of neural circuits and how they …
Giant lungfish genome elucidates the conquest of land by vertebrates
Lungfishes belong to lobe-fined fish (Sarcopterygii) that, in the Devonian
period,'conquered'the land and ultimately gave rise to all land vertebrates, including …
period,'conquered'the land and ultimately gave rise to all land vertebrates, including …
Toward identification of functional sequences and variants in noncoding DNA
Understanding the noncoding part of the genome, which encodes gene regulation, is
necessary to identify genetic mechanisms of disease and translate findings from genome …
necessary to identify genetic mechanisms of disease and translate findings from genome …
Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
I Delgado, G Giovinazzo, S Temiño, Y Gauthier… - Nature …, 2021 - nature.com
Meis1 and Meis2 are homeodomain transcription factors that regulate organogenesis
through cooperation with Hox proteins. Elimination of Meis genes after limb induction has …
through cooperation with Hox proteins. Elimination of Meis genes after limb induction has …
Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution
Detecting the genomic changes underlying phenotypic changes between species is a main
goal of evolutionary biology and genomics. Evolutionary theory predicts that changes in cis …
goal of evolutionary biology and genomics. Evolutionary theory predicts that changes in cis …
Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages
Loss of limbs evolved many times in squamate reptiles. Here we investigated the genomic
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …
Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud
Sonic hedgehog (Shh) is essential for limb development, and the mechanisms that govern
the propagation and maintenance of its expression has been well studied; however, the …
the propagation and maintenance of its expression has been well studied; however, the …
Differential analysis of chromatin accessibility and histone modifications for predicting mouse developmental enhancers
Enhancers are distal cis-regulatory elements that modulate gene expression. They are
depleted of nucleosomes and enriched in specific histone modifications; thus, calling DNase …
depleted of nucleosomes and enriched in specific histone modifications; thus, calling DNase …
A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2
A lingering question in developmental biology has centered on how transcription factors with
widespread distribution in vertebrate embryos can perform tissue-specific functions. Here …
widespread distribution in vertebrate embryos can perform tissue-specific functions. Here …
Similarities and differences in the regulation of HoxD genes during chick and mouse limb development
N Yakushiji-Kaminatsui, L Lopez-Delisle, CC Bolt… - PLoS …, 2018 - journals.plos.org
In all tetrapods examined thus far, the development and patterning of limbs require the
activation of gene members of the HoxD cluster. In mammals, they are regulated by a …
activation of gene members of the HoxD cluster. In mammals, they are regulated by a …