The life and times of a tRNA

EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications

T Chujo, K Tomizawa - The FEBS journal, 2021 - Wiley Online Library
tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …

The role of RNA modifications in the regulation of tRNA cleavage

SM Lyons, MM Fay, P Ivanov - FEBS letters, 2018 - Wiley Online Library
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …

The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent

R Hauenschild, L Tserovski, K Schmid… - Nucleic acids …, 2015 - academic.oup.com
Abstract The combination of Reverse Transcription (RT) and high-throughput sequencing
has emerged as a powerful combination to detect modified nucleotides in RNA via analysis …

[HTML][HTML] Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates

D Bar-Yaacov, I Frumkin, Y Yashiro, T Chujo… - PLoS …, 2016 - journals.plos.org
The mitochondrial ribosome, which translates all mitochondrial DNA (mtDNA)-encoded
proteins, should be tightly regulated pre-and post-transcriptionally. Recently, we found RNA …

Genome recoding by tRNA modifications

F Tuorto, F Lyko - Open biology, 2016 - royalsocietypublishing.org
RNA modifications are emerging as an additional regulatory layer on top of the primary RNA
sequence. These modifications are particularly enriched in tRNAs where they can regulate …

Modifications of the human tRNA anticodon loop and their associations with genetic diseases

JB Zhou, ED Wang, XL Zhou - Cellular and Molecular Life Sciences, 2021 - Springer
Transfer RNAs (tRNAs) harbor the most diverse posttranscriptional modifications. Among
such modifications, those in the anticodon loop, either on nucleosides or base groups …

[HTML][HTML] Making sense of “nonsense” and more: Challenges and opportunities in the genetic code expansion, in the world of tRNA modifications

OM Lateef, MO Akintubosun, OT Olaoba… - International Journal of …, 2022 - mdpi.com
The evolutional development of the RNA translation process that leads to protein synthesis
based on naturally occurring amino acids has its continuation via synthetic biology, the so …

Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei

AC Kessler, SS Kulkarni, MJ Paulines, MAT Rubio… - RNA biology, 2018 - Taylor & Francis
Retrograde transport of tRNAs from the cytoplasm to the nucleus was first described in
Saccharomyces cerevisiae and most recently in mammalian systems. Although the function …

The role of intracellular compartmentalization on tRNA processing and modification

AC Kessler, G Silveira d'Almeida, JD Alfonzo - RNA biology, 2018 - Taylor & Francis
ABSTRACT A signature of most eukaryotic cells is the presence of intricate membrane
systems. Intracellular organization presumably evolved to provide order, and add layers for …