Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …

Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with
different cellular localizations. It is involved in multiple cellular functions, including energy …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly
dysregulated in human malignancies by processes driven by RAS or RAF oncogenes …

Prohibitin (PHB) was originally isolated and characterized as an anti-proliferative gene in rat
liver. The evolutionarily conserved PHB gene encodes two human protein isoforms with …

Over the last three decades, the scaffold proteins prohibitins-1 and-2 (PHB1/2) have
emerged as key signaling proteins regulating a myriad of signaling pathways in health and …

Background Owing to the lack of effective treatment options, early metastasis remains the
major cause of pancreatic ductal adenocarcinoma (PDAC) recurrence and mortality …

As a member of PHB (prohibitin1) family, PHB plays important roles in many cancers, but its
property in bladder carcinoma aggressiveness is unknown. This research was to explore the …

Background The biological function of squalene epoxidase (SQLE), an important rate‐
limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin …

A decline in mitochondrial function has long been associated with age-related health
decline. Several lines of evidence suggest that interventions that stimulate mitochondrial …