Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
[HTML][HTML] Coping with the forced swim stressor: Current state-of-the-art
ML Molendijk, ER de Kloet - Behavioural brain research, 2019 - Elsevier
The forced swim test (FST) for rodents does not model despair or helplessness. It also is not
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
Coping with the forced swim stressor: towards understanding an adaptive mechanism
ER De Kloet, ML Molendijk - Neural plasticity, 2016 - Wiley Online Library
In the forced swim test (FST) rodents progressively show increased episodes of immobility if
immersed in a beaker with water from where escape is not possible. In this test, a compound …
immersed in a beaker with water from where escape is not possible. In this test, a compound …
How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress
JM McKlveen, B Myers… - Journal of …, 2015 - Wiley Online Library
Responding to real or potential threats in the environment requires the coordination of
autonomic, neuroendocrine and behavioural processes to promote adaptation and survival …
autonomic, neuroendocrine and behavioural processes to promote adaptation and survival …
Rodent models of depression: neurotrophic and neuroinflammatory biomarkers
M Stepanichev, NN Dygalo, G Grigoryan… - BioMed research …, 2014 - Wiley Online Library
Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory …
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory …
Top‐down and bottom‐up control of stress‐coping
ER de Kloet, SF de Kloet, CS de Kloet… - Journal of …, 2019 - Wiley Online Library
In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic‐
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits
NC Woodward, A Haghani, RG Johnson… - Translational …, 2018 - nature.com
Exposure to traffic-related air pollution (TRAP) is associated with a range of
neurodevelopmental disorders in human populations. In rodent models, prenatal TRAP …
neurodevelopmental disorders in human populations. In rodent models, prenatal TRAP …
Forced swim stressor: Trends in usage and mechanistic consideration
ML Molendijk, ER de Kloet - European Journal of Neuroscience, 2022 - Wiley Online Library
The acquired immobility response during the “forced swim test (FST)” is not a rodent model
of depression, but the test has some validity in predicting a compound's antidepressant …
of depression, but the test has some validity in predicting a compound's antidepressant …
Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice
I Es-Safi, H Mechchate, A Amaghnouje, A Elbouzidi… - Plants, 2021 - mdpi.com
Mental disorders are psychological symptoms that impact multiple areas of an individual's
life. Depression and anxiety are chronic illnesses described as the most prevalent stress …
life. Depression and anxiety are chronic illnesses described as the most prevalent stress …