Animal models of depression: what can they teach us about the human disease?

M Becker, A Pinhasov, A Ornoy - Diagnostics, 2021 - mdpi.com
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

[HTML][HTML] Coping with the forced swim stressor: Current state-of-the-art

ML Molendijk, ER de Kloet - Behavioural brain research, 2019 - Elsevier
The forced swim test (FST) for rodents does not model despair or helplessness. It also is not
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …

Coping with the forced swim stressor: towards understanding an adaptive mechanism

ER De Kloet, ML Molendijk - Neural plasticity, 2016 - Wiley Online Library
In the forced swim test (FST) rodents progressively show increased episodes of immobility if
immersed in a beaker with water from where escape is not possible. In this test, a compound …

How to study anxiety and depression in rodent models of chronic pain?

M Kremer, LJ Becker, M Barrot… - European Journal of …, 2021 - Wiley Online Library
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress

JM McKlveen, B Myers… - Journal of …, 2015 - Wiley Online Library
Responding to real or potential threats in the environment requires the coordination of
autonomic, neuroendocrine and behavioural processes to promote adaptation and survival …

Rodent models of depression: neurotrophic and neuroinflammatory biomarkers

M Stepanichev, NN Dygalo, G Grigoryan… - BioMed research …, 2014 - Wiley Online Library
Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory …

Top‐down and bottom‐up control of stress‐coping

ER de Kloet, SF de Kloet, CS de Kloet… - Journal of …, 2019 - Wiley Online Library
In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic‐
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …

Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits

NC Woodward, A Haghani, RG Johnson… - Translational …, 2018 - nature.com
Exposure to traffic-related air pollution (TRAP) is associated with a range of
neurodevelopmental disorders in human populations. In rodent models, prenatal TRAP …

Forced swim stressor: Trends in usage and mechanistic consideration

ML Molendijk, ER de Kloet - European Journal of Neuroscience, 2022 - Wiley Online Library
The acquired immobility response during the “forced swim test (FST)” is not a rodent model
of depression, but the test has some validity in predicting a compound's antidepressant …

Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice

I Es-Safi, H Mechchate, A Amaghnouje, A Elbouzidi… - Plants, 2021 - mdpi.com
Mental disorders are psychological symptoms that impact multiple areas of an individual's
life. Depression and anxiety are chronic illnesses described as the most prevalent stress …