With multiple omics strategies being applied to several cancer genomics projects,
researchers have the opportunity to develop a rational planning of targeted cancer therapy …

Hedgehog (Hh) signaling is crucially involved in tumorigenesis. This study aimed to assess
the role of Hh signaling in the regulation of epithelial-mesenchymal transition (EMT) …

A common procedure performed throughout biomedical research is the selection and
isolation of biological entities such as organelles, cells and organoids from a mixed …

Background Pancreatic cancer is one of the most aggressive cancers, and the
aggressiveness of pancreatic cancer is in part due to its intrinsic and extrinsic drug …

Purpose: Although the existence of cancer stem cells (CSC) in adenoid cystic carcinoma
(ACC) has been proposed, lack of assays for their propagation and uncertainty about …

Considerable evidence points to cancer stem-like cells (CSCs) as responsible for promoting
progression, metastasis, and drug resistance. Without damage to the cell biological …

Primary patient samples are the gold standard for molecular investigations of tumor biology
yet are difficult to acquire, heterogeneous in nature and variable in size. Patient‐derived …

Aim: To establish a pancreatic cancer stem cell model using human pancreatic cancer cells
in nude mice to provide a platform for pancreatic cancer stem cell research. Materials and …

Patient derived xenograft (PDX) is defined as a growth of patients' tumor in the xenograft
setting. The evolution of cancer model in animal has a century old history. The most single …

Advancing knowledge of biological mechanisms has come to depend upon genetic
manipulation of cells and organisms, relying upon cellular cloning methods that remain …