Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …

Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

An efficient and environmentally friendly method was established for designing novel 3-
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …

Anti-inflammatory medications are one of the most commonly preferred over-the-counter
medications because inflammation and pain are closely related and caused by various …

Chronic inflammation contributes to a number of diseases. Therefore, control of the
inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory …

In an attempt to improve and develop biologically potential anticancer agents, synthesis of
new anticancer agents are in progress. This study focused on the synthesis of novel …

This study aims to synthesize some novel pyrazolo [1, 5‐a] pyrimidine derivatives, and
investigate their biological activities. These compounds exhibited good to high antioxidant …

New series of pyrazoles 4a–c and pyrazolopyrimidines 5a–f had been constructed. The
newly synthesized compounds were assessed for their antimicrobial activity towards E. coli …