Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …

APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that
mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell …

More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified
as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this …

The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG)
subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal …

Inborn errors of human IL-17 immunity underlie chronic mucoc... : Current Opinion in Allergy and
Clinical Immunology Inborn errors of human IL-17 immunity underlie chronic mucocutaneous …

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent
infections affecting the nails, skin and oral and genital mucosae caused by Candida spp …

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent
infections of the skin, nail, oral, and genital mucosae with Candida species, mainly C …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Mice with defective IL‐17 immunity display a broad vulnerability to various infectious agents
at diverse mucocutaneous surfaces. In humans, the study of patients with various primary …