Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …

Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …

Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …

Hematopoietic stem cell transplantation is an effective regenerative therapy for many
malignant, inherited, or autoimmune diseases. However, our understanding of reconstituted …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse
models and may drive systemic inflammation. Skin TRMs of patients undergoing allogeneic …

Memory T cells form an essential part of immunological memory, which can last for years or
even a lifetime. Much experimental work has shown that the individual cells that make up the …

Tissue-resident memory T cells (TRM) have recently emerged as crucial cellular players for
host defense in a wide variety of tissues and barrier sites. Insights into the maintenance and …

Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …