Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …

Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the
development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing …

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms
in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in …

Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart
growth occurs through cardiomyocyte proliferation, whereas postnatal heart growth involves …