The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα)
belongs to the nuclear receptor (NR) family, and is a heme-binding component of the …

Despite the high prevalence of acute kidney injury (AKI), the therapeutic approaches for AKI
are disappointing. This deficiency stems from the poor understanding of the pathogenesis of …

Leptin, an adipocyte-derived satiety hormone, has been previously linked to
cardioprotection. We have shown before that leptin conferred resistance to ischemic …

Leptin is an adipokine of pleiotropic effects linked to energy metabolism, satiety, the immune
response, and cardioprotection. We have recently shown that leptin causally conferred …

Disruption of circadian rhythms is associated with neurological, endocrine and metabolic
pathologies. We have recently shown that mice lacking functional type 3 deiodinase (DIO3) …

αMUPA transgenic mice spontaneously consume less food compared with their wild type
(WT) ancestors due to endogenously increased levels of the satiety hormone leptin. αMUPA …

Circadian disruptions precede high-fat diet (HFD)-induced obesity (DIO). Deviation of the
endogenous circadian rhythm period length (tau) from 24 hours correlates with mice inter …

The process of biological aging or senescence refers to the gradual loss of homeostasis and
subsequent loss of function–leading to higher chances of mortality. Many mechanisms and …

We investigated whether long-lived weight-reduced αMUPA mice differ from their wild types
in postnatal body composition and leptin level, and whether these differences are affected …