With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Faecal incontinence, which is defined by the unintentional loss of solid or liquid stool, has a
worldwide prevalence of≤ 7% in community-dwelling adults and can markedly impair …

The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

Background Anorectal manometry (ARM) comprehensively assesses anorectal
sensorimotor functions. Purpose This review examines the indications, techniques …

Abstract Purpose of Review Objective measurement of anorectal sensorimotor function is a
requisite component in the clinical evaluation of patients with intractable symptoms of …

A valid biomarker is defined as 'a characteristic that is measured and evaluated as an
indicator of normal biological processes, pathogenic processes or pharmacological …

Background & Aims The utility of high-resolution anorectal manometry (HR-ARM) for
diagnosing defecatory disorders (DDs) is unclear because healthy people may have …

Benign anorectal disorders of structure and function are common in clinical practice. These
guidelines summarize the preferred approach to the evaluation and management of …

Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous
system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and …

The autonomic nervous system delicately regulates the function of several target organs,
including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may …