WNT signaling and bone: lessons from skeletal dysplasias and disorders

Y Huybrechts, G Mortier, E Boudin… - Frontiers in …, 2020 - frontiersin.org
Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

Coreceptor functions of cell surface heparan sulfate proteoglycans

K Hayashida, RS Aquino… - American Journal of …, 2022 - journals.physiology.org
Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …

Syndecan receptors: pericellular regulators in development and inflammatory disease

S Gopal, S Arokiasamy, C Pataki… - Open …, 2021 - royalsocietypublishing.org
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

HY Kim, JW Um, J Ko - Progress in Neurobiology, 2021 - Elsevier
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

X‐Linked intellectual disability update 2022

CE Schwartz, RJ Louie, A Toutain… - American Journal of …, 2023 - Wiley Online Library
Genes that are involved in the transcription process, mitochondrial function, glycoprotein
metabolism, and ubiquitination dominate the list of 21 new genes associated with X‐linked …

Congenital disorders of deficiency in glycosaminoglycan biosynthesis

S Mizumoto, S Yamada - Frontiers in genetics, 2021 - frontiersin.org
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …

Heparan sulfate proteoglycans (HSPGs) of the ocular lens

TFL Wishart, FJ Lovicu - Progress in Retinal and Eye Research, 2023 - Elsevier
Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …

Zebrafish endochondral growth zones as they relate to human bone size, shape and disease

P Le Pabic, DB Dranow, DJ Hoyle… - Frontiers in …, 2022 - frontiersin.org
Research on the genetic mechanisms underlying human skeletal development and disease
have largely relied on studies in mice. However, recently the zebrafish has emerged as a …

[HTML][HTML] Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfate diversity

MO Ouidja, DSF Biard, MB Huynh, X Laffray… - Essays in …, 2024 - portlandpress.com
Heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PG) consist of a core
protein to which the glycosaminoglycan (GAG) chains, HS or CS, are attached through a …

The function of glypicans in the mammalian embryo

J Filmus - American Journal of Physiology-Cell Physiology, 2022 - journals.physiology.org
Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by
a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the …