WNT signaling and bone: lessons from skeletal dysplasias and disorders
Y Huybrechts, G Mortier, E Boudin… - Frontiers in …, 2020 - frontiersin.org
Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …
growth. Throughout the years, the molecular defect underlying many of the diseases has …
Coreceptor functions of cell surface heparan sulfate proteoglycans
K Hayashida, RS Aquino… - American Journal of …, 2022 - journals.physiology.org
Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …
triggering specific cellular responses. These interactions are frequently regulated by …
Syndecan receptors: pericellular regulators in development and inflammatory disease
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …
development and specifying neural circuit properties via the formation of multifarious …
X‐Linked intellectual disability update 2022
CE Schwartz, RJ Louie, A Toutain… - American Journal of …, 2023 - Wiley Online Library
Genes that are involved in the transcription process, mitochondrial function, glycoprotein
metabolism, and ubiquitination dominate the list of 21 new genes associated with X‐linked …
metabolism, and ubiquitination dominate the list of 21 new genes associated with X‐linked …
Congenital disorders of deficiency in glycosaminoglycan biosynthesis
S Mizumoto, S Yamada - Frontiers in genetics, 2021 - frontiersin.org
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …
Heparan sulfate proteoglycans (HSPGs) of the ocular lens
TFL Wishart, FJ Lovicu - Progress in Retinal and Eye Research, 2023 - Elsevier
Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …
pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity …
Zebrafish endochondral growth zones as they relate to human bone size, shape and disease
P Le Pabic, DB Dranow, DJ Hoyle… - Frontiers in …, 2022 - frontiersin.org
Research on the genetic mechanisms underlying human skeletal development and disease
have largely relied on studies in mice. However, recently the zebrafish has emerged as a …
have largely relied on studies in mice. However, recently the zebrafish has emerged as a …
[HTML][HTML] Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfate diversity
MO Ouidja, DSF Biard, MB Huynh, X Laffray… - Essays in …, 2024 - portlandpress.com
Heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PG) consist of a core
protein to which the glycosaminoglycan (GAG) chains, HS or CS, are attached through a …
protein to which the glycosaminoglycan (GAG) chains, HS or CS, are attached through a …
The function of glypicans in the mammalian embryo
J Filmus - American Journal of Physiology-Cell Physiology, 2022 - journals.physiology.org
Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by
a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the …
a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the …