This review gives an account of how the cell repairs DNA damage and presents evidence
that DNA damage contributes to aging and cancer, with the outcome dependent on the type …

The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal genetic disorder characterized by
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Specific point mutations in lamin A gene have been shown to accelerate aging in humans
and mice. Particularly, a de novo mutation at G608G position impairs lamin A processing to …

Abnormal splicing of LMNA gene or aberrant processing of prelamin A results in progeroid
syndrome. Here we show that lamin A interacts with and activates SIRT1. SIRT1 exhibits …

Nuclear structure and function are governed by lamins, which are intermediate filaments that
mostly consist of α-helices. Different lamin assembly models have been proposed based on …

We report crosstalk between three senescence‐inducing conditions, DNA damage response
(DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive …

The process of aging refers to the decay of an organism's structure and function, in which
molecular and cellular modifications can have various effects at the individual level over the …