NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …

Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …

The cytoplasmic peptide: N-glycanase (PNGase; Ngly1 in mice) is a deglycosylating enzyme
involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) process. The …

The cytoplasmic peptide: N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …

Mitochondrial respiratory chain (RC) diseases and congenital disorders of glycosylation
(CDG) share extensive clinical overlap but are considered to have distinct cellular …

Abstract Peptide: N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …

Desialylation is a pivotal part of sialic acid metabolism, which initiates the catabolism of
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …

N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …

The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …

Aberrant changes of N-glycan modifications on proteins have been linked to various
diseases including different cancers, suggesting possible avenue for exploring their …