The cytoplasmic peptide: N-glycanase (NGLY1)—Structure, expression and cellular functions
T Suzuki, C Huang, H Fujihira - Gene, 2016 - Elsevier
NGLY1/Ngly1 is a cytosolic peptide: N-glycanase, ie. de-N-glycosylating enzyme acting on
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated …
Generation and degradation of free asparagine-linked glycans
Y Harada, H Hirayama, T Suzuki - Cellular and molecular life sciences, 2015 - Springer
Asparagine (N)-linked protein glycosylation, which takes place in the eukaryotic
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
endoplasmic reticulum (ER), is important for protein folding, quality control and the …
Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells
The cytoplasmic peptide: N-glycanase (PNGase; Ngly1 in mice) is a deglycosylating enzyme
involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) process. The …
involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) process. The …
[HTML][HTML] Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene
H Fujihira, Y Masahara-Negishi, M Tamura… - PLoS …, 2017 - journals.plos.org
The cytoplasmic peptide: N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …
that is highly conserved among eukaryotes. It was recently reported that subjects harboring …
Mitochondrial function requires NGLY1
J Kong, M Peng, J Ostrovsky, YJ Kwon, O Oretsky… - Mitochondrion, 2018 - Elsevier
Mitochondrial respiratory chain (RC) diseases and congenital disorders of glycosylation
(CDG) share extensive clinical overlap but are considered to have distinct cellular …
(CDG) share extensive clinical overlap but are considered to have distinct cellular …
The cytoplasmic peptide:N-glycanase (Ngly1)—basic science encounters a human genetic disorder
T Suzuki - The journal of biochemistry, 2015 - academic.oup.com
Abstract Peptide: N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …
N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in …
Desialylation in physiological and pathological processes: New target for diagnostic and therapeutic development
M Wei, PG Wang - Progress in Molecular Biology and Translational …, 2019 - Elsevier
Desialylation is a pivotal part of sialic acid metabolism, which initiates the catabolism of
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …
Catabolism of N-glycoproteins in mammalian cells: Molecular mechanisms and genetic disorders related to the processes
T Suzuki - Molecular aspects of medicine, 2016 - Elsevier
N-glycans on glycoproteins serve as one of the most important co-and post-translational
modifications of proteins, and it has been well established that they play pivotal roles in …
modifications of proteins, and it has been well established that they play pivotal roles in …
Glycan quality control in and out of the endoplasmic reticulum of mammalian cells
Y Harada, Y Ohkawa, K Maeda… - The FEBS Journal, 2022 - Wiley Online Library
The endoplasmic reticulum (ER) is equipped with multiple quality control systems (QCS) that
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …
are necessary for shaping the glycoproteome of eukaryotic cells. These systems facilitate the …
Mass spectrometric profiling reveals association of N-glycan patterns with epithelial ovarian cancer progression
H Chen, Z Deng, C Huang, H Wu, X Zhao… - Tumor Biology, 2017 - journals.sagepub.com
Aberrant changes of N-glycan modifications on proteins have been linked to various
diseases including different cancers, suggesting possible avenue for exploring their …
diseases including different cancers, suggesting possible avenue for exploring their …