The CCA sequence is conserved at the 3′ end of all mature tRNA molecules to function as
the site of amino acid attachment. This sequence is acquired and maintained by stepwise …

RNA-processing pathways are at the centre of regulation of gene expression. All RNA
transcripts undergo multiple maturation steps in addition to covalent chemical modifications …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

Since convergent evolution of enzyme active sites was first identified in serine proteases,
other individual instances of this phenomenon have been documented. However, a …

Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the
maturation or repair of the functional 3′ end of tRNAs by means of the addition of the …

Lincosamides make up an important class of antibiotics used against a wide range of
pathogens, including methicillin-resistant Staphylococcus aureus. Predictably, lincosamide …

The 3′-terminal CCA nucleotide sequence (positions 74–76) of transfer RNA is essential
for amino acid attachment and interaction with the ribosome,, during protein synthesis. The …

CCA-adding enzymes (tRNA nucleotidyltransferases) are responsible for the maturation or
repair of the functional 3′ end of tRNAs. These enzymes are remarkable because they …

RNA polymerases are important enzymes involved in the realization of the genetic
information encoded in the genome. Thereby, DNA sequences are used as templates to …

RNA uridylylation plays a pivotal role in the biogenesis and metabolism of functional RNAs,
and regulates cellular gene expression. RNA uridylylation is catalyzed by a subset of …