The mitochondrial pathway of apoptosis part II: the BCL-2 protein family
DR Green - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
We are now near the top of the mitochondrial pathway of apoptosis, at the point before the
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …
[HTML][HTML] Autophagy during viral infection—a double-edged sword
Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …
Multiple functions of BCL-2 family proteins
JM Hardwick, L Soane - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …
family of interacting partners includes inhibitors and inducers of cell death. Together they …
The evolution of regulated cell death pathways in animals and their evasion by pathogens
B Tummers, DR Green - Physiological reviews, 2022 - journals.physiology.org
The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …
associated with protection from or susceptibility to infections. Among the mechanisms that …
Targeting proteases: successes, failures and future prospects
B Turk - Nature reviews Drug discovery, 2006 - nature.com
Until fairly recently, proteases were considered primarily to be protein-degrading enzymes.
However, this view has dramatically changed and proteases are now seen as extremely …
However, this view has dramatically changed and proteases are now seen as extremely …
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
A Strasser, S Cory, JM Adams - The EMBO journal, 2011 - embopress.org
Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …
Necrotic death as a cell fate
WX Zong, CB Thompson - Genes & development, 2006 - genesdev.cshlp.org
Organismal homeostasis depends on an intricate balance between cell death and renewal.
Early pathologists recognized that this balance could be disrupted by the extensive damage …
Early pathologists recognized that this balance could be disrupted by the extensive damage …
Autophagy and viral infection
Autophagy is an intracellular recycling process that maintains cellular homeostasis by
orchestrating immunity upon viral infection. Following viral infection, autophagy is often …
orchestrating immunity upon viral infection. Following viral infection, autophagy is often …
Ways of dying: multiple pathways to apoptosis
JM Adams - Genes & development, 2003 - genesdev.cshlp.org
In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …
Role of the crosstalk between autophagy and apoptosis in cancer
Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis.
Autophagy is normally a cell‐survival pathway involving the degradation and recycling of …
Autophagy is normally a cell‐survival pathway involving the degradation and recycling of …