Although the genetic origins underpinning congenital heart disease (CHD) have been
extensively studied, genes, by themselves, do not entirely predict phenotypes, which result …

Abstract m6A (N6‑methyladenosine) is the most common and abundant apparent
modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and …

Objective: Regulatory T cells (Tregs) are critical immune modulators to maintain immune
homeostasis and limit pulmonary hypertension (PH). This study was aimed to identify Treg …

Pulmonary arterial hypertension, or PAH, is a condition that is characterized by pulmonary
artery pressures above 20 mmHg (at rest). In the treatment of PAH, the pulmonary vascular …

Prolactin (PRL) is a polypeptide hormone that is mainly synthesized and secreted by the
lactotroph cells of the pituitary. There are two main isoforms of PRL: 23‐kDa PRL (named full …

Cellular metabolism influences all aspects of cellular function and is crucial for overall
organismal health. Metabolic disorders related to cardiovascular health can lead to …

Background Thermal ablation is a minimally invasive treatment for non-small cell lung
cancer (NSCLC). Aside from causing an immediate direct tumour cell injury, the effects of …

This study examines the impact of triacetyl-diacyllactone (ADA) on the proliferation and
migration of pulmonary artery smooth muscle cells (PASMCs) and elucidates its underlying …

Pulmonary hypertension (PH) is a multifaceted illness causing clinical manifestations like
dyspnea, fatigue, and cyanosis. If left untreated, it often evolves into irreversible pulmonary …

Background Metabolic abnormalities are considered to play a key regulatory role in vascular
remodeling of pulmonary arterial hypertension. However, to date, there is a paucity of …