For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Tetratrico peptide repeat (TPR) proteins have several interesting properties, including their
folding characteristics, modular architecture and range of binding specificities. In the past …

NADPH oxidase is an enzyme that catalyzes the production of superoxide from oxygen and
NADPH. It is a complex enzyme consisting of two membrane-bound components and three …

NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in
prokaryotes, and play crucial roles in a variety of biological processes, such as host defense …

Flavocytochrome b 558 is the catalytic core of the respiratory-burst oxidase, an enzyme
complex that catalyzes the NADPH-dependent reduction of O 2 into the superoxide anion O …

The NADPH oxidase of professional phagocytes is a crucial component of the innate
immune response due to its fundamental role in the production of reactive oxygen species …

Neutrophils play an essential role in the body's innate defense against pathogens and are
one of the primary mediators of the inflammatory response. To defend the host, neutrophils …

The NADPH oxidase complex is involved in the destruction of phagocytosed pathogens
through the production of reactive oxygen species. This activatable complex consists of a …

Stimulated phagocytes undergo a burst in respiration whereby molecular oxygen is
converted to superoxide anion through the action of an NADPH-dependent oxidase. The …

The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …