[HTML][HTML] Where is the error? Hierarchical predictive coding through dendritic error computation
Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …
Developmental mechanisms underlying the evolution of human cortical circuits
P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans
Brain function is a product of the balance between excitatory and inhibitory (E/I) brain
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …
Illuminating dendritic function with computational models
P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
[HTML][HTML] The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness
The neurobiological mechanisms of arousal and anesthesia remain poorly understood.
Recent evidence highlights the key role of interactions between the cerebral cortex and the …
Recent evidence highlights the key role of interactions between the cerebral cortex and the …
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease
Synaptic disturbances in excitatory to inhibitory (E/I) balance in forebrain circuits are thought
to contribute to the progression of Alzheimer's disease (AD) and dementia, although direct …
to contribute to the progression of Alzheimer's disease (AD) and dementia, although direct …
[HTML][HTML] Regulation of circuit organization and function through inhibitory synaptic plasticity
Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly
In this review, we discuss the significance of the synaptic excitation/inhibition (E/I) balance in
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …
Keeping your brain in balance: Homeostatic regulation of network function
W Wen, GG Turrigiano - Annual Review of Neuroscience, 2024 - annualreviews.org
To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …
microcircuits must be capable of reconfiguring in response to experience, while carefully …
Dysregulation of GABAergic signaling in neurodevelomental disorders: targeting cation-chloride co-transporters to re-establish a proper E/I balance
The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …