Small molecule selenium-containing compounds: Recent development and therapeutic applications
H Chuai, SQ Zhang, H Bai, J Li, Y Wang, J Sun… - European Journal of …, 2021 - Elsevier
Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …
participates in the functions of selenoprotein in several manners. In recent years, Se has …
Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation
C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …
A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes
S Wei, P Xu, Z Yao, X Cui, X Lei, L Li, Y Dong, W Zhu… - Acta biomaterialia, 2021 - Elsevier
Diabetic wound healing remains a major challenge due to its vulnerability to bacterial
infection, as well as the less vascularization and prolonged inflammatory phase. In this …
infection, as well as the less vascularization and prolonged inflammatory phase. In this …
Antimicrobials functioning through ros-mediated mechanisms: Current insights
A Vaishampayan, E Grohmann - Microorganisms, 2021 - mdpi.com
Antibiotic resistance and infections caused by multidrug-resistant bacteria are global health
concerns. Reducing the overuse and misuse of antibiotics is the primary step toward …
concerns. Reducing the overuse and misuse of antibiotics is the primary step toward …
The role of the thioredoxin system in brain diseases
The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …
Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal
S Alfei, GC Schito, AM Schito, G Zuccari - International Journal of …, 2024 - mdpi.com
The increasing emergence of multidrug-resistant (MDR) pathogens causes difficult-to-treat
infections with long-term hospitalizations and a high incidence of death, thus representing a …
infections with long-term hospitalizations and a high incidence of death, thus representing a …
Oxidative stress-generating antimicrobials, a novel strategy to overcome antibacterial resistance
Antimicrobial resistance is becoming one of the most important human health issues.
Accordingly, the research focused on finding new antibiotherapeutic strategies is again …
Accordingly, the research focused on finding new antibiotherapeutic strategies is again …
Mechanisms of ebselen as a therapeutic and its pharmacology applications
J Wang, P Wang, C Dong, Y Zhao, J Zhou… - Future medicinal …, 2020 - Taylor & Francis
Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …
Chemopreventive and anticancer property of selenoproteins in obese breast cancer
S Bevinakoppamath, AM Saleh Ahmed… - Frontiers in …, 2021 - frontiersin.org
Obesity is a significant risk factor for various cancers including breast cancer resulting in an
increased risk of recurrence as well as morbidity and mortality. Extensive studies on various …
increased risk of recurrence as well as morbidity and mortality. Extensive studies on various …
Selenium as an interesting option for the treatment of Chagas disease: A review
V Alcolea, S Pérez-Silanes - European journal of medicinal chemistry, 2020 - Elsevier
Chagas disease is one of the most prevalent tropical neglected diseases and causes high
mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox …
mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox …