[HTML][HTML] Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
G Welch, LH Tsai - EMBO reports, 2022 - embopress.org
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease
Synaptic dysfunction is an early mechanism in Alzheimer's disease that involves
progressively larger areas of the brain over time. However, how it starts and propagates is …
progressively larger areas of the brain over time. However, how it starts and propagates is …
Connecting the “dots”: from free radical lipid autoxidation to cell pathology and disease
Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is
increasingly implicated in various diseases but also recognized as a key part of normal cell …
increasingly implicated in various diseases but also recognized as a key part of normal cell …
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants
J Hoogmartens, R Cacace… - … & Dementia: Diagnosis …, 2021 - Wiley Online Library
Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome
L Flores-Aguilar, MF Iulita, O Kovecses, MD Torres… - Brain, 2020 - academic.oup.com
Epidemiological and experimental studies suggest that a disease-aggravating
neuroinflammatory process is present at preclinical stages of Alzheimer's disease. Given …
neuroinflammatory process is present at preclinical stages of Alzheimer's disease. Given …
[HTML][HTML] Alzheimer's disease pathophysiology in the retina
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
What is 'Alzheimer's disease'? The neuropathological heterogeneity of clinically defined Alzheimer's dementia
RI Mehta, JA Schneider - Current opinion in neurology, 2021 - journals.lww.com
Alzheimer's dementia is a pathologically heterogeneous and biologically multilayered
disease. Recent studies and exercises in nomenclature reveal shortcomings in existing …
disease. Recent studies and exercises in nomenclature reveal shortcomings in existing …
Delivering the promise of gene therapy with nanomedicines in treating central nervous system diseases
Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …
Human herpesviruses 6A and 6B in brain diseases: association versus causation
AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …