Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Objectives: The aim of this study was to describe the clinical profile associated with triple
sarcomere gene mutations in a large hypertrophic cardiomyopathy (HCM) cohort …

Progress in precision medicine is limited by insufficient knowledge of transcriptomic or
proteomic features in involved tissues that define pathobiological differences between …

Background—Multiple likely pathogenic/pathogenic (LP/P;≥ 2) variants in patients with
hypertrophic cardiomyopathy were described 10 years ago with a prevalence of 5%. We …

BACKGROUND: Risk stratification strategies employing sarcomere gene mutational
analysis have proved imprecise in identifying high-risk patients with hypertrophic …

Over the last 2 decades, major advances have been made in our identification and
understanding of the genetic basis of cardiovascular disease. More than 40 cardiovascular …

Background—Today, mutations in more than 30 different genes have been found to cause
inherited cardiomyopathies, some associated with very poor prognosis. However, because …

Background—Junctophilin-2 (JPH2), a protein expressed in the junctional membrane
complex, is necessary for proper intracellular calcium (Ca2+) signaling in cardiac myocytes …

Congenital heart disease (CHD) is among the most prevalent and fatal of all birth defects.
Deciphering its causes, however, is complicated, as many patients affected by CHD have no …