Cancer is a multistage and complex process characterized by molecular alterations that
underlie all three phases of its development:(i) initiation,(ii) promotion and (iii) progression …

Elevated levels of both reactive oxygen species (ROS) and DNA methylation are
characteristic of various types of cancer cells. However, the relation between these two is not …

Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Hepatocellular carcinoma (HCC) typically has poor prognosis, because it is often diagnosed
at an advanced stage. Heterogeneous phenotypic and genetic traits of affected individuals …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

The incidence of both type 2 diabetes mellitus (T2DM) and multiple cancer types are rapidly
increasing worldwide. Several studies documented that T2DM is closely associated with an …

Purpose: MicroRNA (miRNA) is a new class of small, noncoding RNA. The purpose of this
study was to determine if miRNAs are differentially expressed in hepatocellular carcinoma …

Abstract Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food
commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has …

Liver cancer is the third leading cause of cancer-related death worldwide. Advances in
sequencing technologies have enabled the examination of liver cancer genomes at high …

Alterations in microRNA (miRNA) expression in both human and animal models have been
linked to many forms of cancer. Such miRNAs, which act directly as repressors of gene …