[HTML][HTML] Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

AP Caccavano, S Kimmel, A Vlachos, V Mahadevan… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Opioid receptors within the CNS regulate pain sensation and mood and are key targets for
drugs of abuse. Within the adult rodent hippocampus (HPC), μ-opioid receptor agonists …

Early expression of GluN2A-containing NMDA receptors in a model of fragile X syndrome

TG Banke, SF Traynelis… - Journal of …, 2024 - journals.physiology.org
NMDA-type glutamate receptors (NMDARs) play a crucial role in synaptogenesis, circuit
development, and synaptic plasticity, serving as fundamental components in cellular models …

Sodium para‐aminosalicylic acid attenuates combined manganese/iron‐induced cortical synaptic damage in rats

HX Song, YH Xie, YY Fang, JJ Lin… - Basic & Clinical …, 2024 - Wiley Online Library
We established experimental models of manganese (Mn) and iron (Fe) exposure in vitro and
in vivo, and addressed the effects of manganese and iron combined exposure on the …

Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors

L Montanucci, T Brünger, N Bhattarai, CM Boßelmann… - medRxiv, 2024 - medrxiv.org
Genetic variants in genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of
the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and …

Community effort to unravel the complex human neuronal landscape exemplified for the striatum

J Schultze, S Agrawal, R Scholz, C Hartmann, L Hetzel… - 2024 - researchsquare.com
Precise determination of cellular identity and molecular phenotypes through advanced high-
throughput technologies is crucial for understanding intricate tissue functions, especially in …