[HTML][HTML] Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements
Epigenomic maps identify gene regulatory elements by their chromatin state. However,
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …
[HTML][HTML] DNA methylation: genomewide distribution, regulatory mechanism and therapy target
DS Kaplun, DN Kaluzhny, EB Prokhortchouk… - Acta …, 2022 - ncbi.nlm.nih.gov
DNA methylation is the most important epigenetic modification involved in the regulation of
transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin …
transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin …
Differential 3D genome architecture and imprinted gene expression: cause or consequence?
B Moindrot, Y Imaizumi, R Feil - Biochemical Society …, 2024 - portlandpress.com
Imprinted genes provide an attractive paradigm to unravel links between transcription and
genome architecture. The parental allele-specific expression of these essential genes …
genome architecture. The parental allele-specific expression of these essential genes …
Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters
Background There is widespread interest in the three-dimensional chromatin conformation
of the genome and its impact on gene expression. However, these studies frequently do not …
of the genome and its impact on gene expression. However, these studies frequently do not …
Corticosteroid‐induced chromatin loop dynamics at the FKBP5 gene
Abstract FKBP5 is a 115‐kb‐long glucocorticoid‐inducible gene implicated in psychiatric
disorders. To investigate the complexities of chromatin interaction frequencies at the FKBP5 …
disorders. To investigate the complexities of chromatin interaction frequencies at the FKBP5 …
Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models
Dysregulation of the imprinted H19/IGF2 locus can lead to Silver-Russell syndrome (SRS) in
humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to …
humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to …
Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith–Wiedemann syndrome-like overgrowth
S Hara, F Matsuhisa, S Kitajima, H Yatsuki… - Communications …, 2024 - nature.com
Beckwith-Wiedemann syndrome (BWS) is caused by a gain of methylation (GOM) at the
imprinting control region within the Igf2-H19 domain on the maternal allele (H19-ICR GOM) …
imprinting control region within the Igf2-H19 domain on the maternal allele (H19-ICR GOM) …
Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism
Z He, J Zhang, Y Chen, C Ai, X Gong, D Xu… - Cell Communication and …, 2023 - Springer
Background Adrenal gland is the synthesis and secretion organ of glucocorticoid, which is
crucial to fetal development and postnatal fate. Recently, we found that prenatal …
crucial to fetal development and postnatal fate. Recently, we found that prenatal …
ICF1-Syndrome-Associated DNMT3B Mutations Prevent De Novo Methylation at a Subset of Imprinted Loci during iPSC Reprogramming
Parent-of-origin-dependent gene expression of a few hundred human genes is achieved by
differential DNA methylation of both parental alleles. This imprinting is required for normal …
differential DNA methylation of both parental alleles. This imprinting is required for normal …
[HTML][HTML] The role of imprinting genes' loss of imprints in cancers and their clinical implications
G Xie, Q Si, G Zhang, Y Fan, Q Li, P Leng… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Genomic imprinting plays an important role in the growth and development of mammals.
When the original imprint status of these genes is lost, known as loss of imprinting (LOI), it …
When the original imprint status of these genes is lost, known as loss of imprinting (LOI), it …