The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has induced severe public healthcare issues and weakened the global economy …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

The currently circulating Omicron sub-variants are the SARS-CoV-2 strains with the highest
number of known mutations. Herein, we found that human angiotensin-converting enzyme 2 …

Molecular dynamics (MD) simulations have revolutionized the modeling of biomolecular
conformations and provided unprecedented insight into molecular interactions. Due to the …

The beginning of the end or the end of the beginning? After two years mastered by
coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The …

To explore the mechanistic origin that determines the binding affinity of SARS-CoV-2 spike
receptor binding domain (RBD) to human angiotensin converting enzyme 2 (ACE2), we …

Frequent mutation and variable immunological protection against vaccination is a common
feature for COVID-19 pandemic. Early detection and confinement remain key to controlling …

CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit …

Large-scale populations in the world have been vaccinated with COVID-19 vaccines,
however, breakthrough infections of SARS-CoV-2 are still growing rapidly due to the …

Heparan sulfate (HS) acts as a co-receptor of angiotensin-converting enzyme 2 (ACE2) by
interacting with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) …