Health benefits of resveratrol: Evidence from clinical studies
AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …
[HTML][HTML] Cerebral autoregulation in hypertension and ischemic stroke: a mini review
Aging and chronic hypertension are associated with dysfunction in vascular smooth muscle,
endothelial cells, and neurovascular coupling. These dysfunctions induce impaired …
endothelial cells, and neurovascular coupling. These dysfunctions induce impaired …
Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction
Y Liu, H Zhang, S Wang, Y Guo… - American Journal …, 2021 - journals.physiology.org
Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …
[HTML][HTML] Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
[HTML][HTML] Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction
Individuals with diabetes are more susceptible to cerebral vascular aging. However, the
underlying mechanisms are not well elucidated. The present study examined whether the …
underlying mechanisms are not well elucidated. The present study examined whether the …
[HTML][HTML] Impaired cerebral blood flow in type 2 diabetes mellitus–a comparative study with subjective cognitive decline, vascular dementia and Alzheimer's disease …
ACM Chau, EYW Cheung, KH Chan, WS Chow… - NeuroImage: Clinical, 2020 - Elsevier
The link between non-demented type 2 diabetes mellitus (T2DM) and different types of
cognitive impairment is controversial. By controlling for co-morbidities such as cerebral …
cognitive impairment is controversial. By controlling for co-morbidities such as cerebral …
Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals
Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms
involved are not well understood. We previously discovered that hyperglycemia induced …
involved are not well understood. We previously discovered that hyperglycemia induced …
[HTML][HTML] iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling
CL Moreno, L Della Guardia, V Shnyder… - Molecular …, 2018 - Springer
Abstract Background Type 2 diabetes (T2D) is a recognized risk factor for the development
of cognitive impairment (CI) and/or dementia, although the exact nature of the molecular …
of cognitive impairment (CI) and/or dementia, although the exact nature of the molecular …
20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility
We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
[HTML][HTML] Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons …
Y Zhong, Y Zhu, T He, W Li, Q Li… - … journal of molecular …, 2019 - spandidos-publications.com
It is not known whether brain‑derived neurotrophic factor (BDNF) protects hippocampal
neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. The …
neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. The …